This beautifully preserved picture shows the Virgin bestowing the scapular—a small piece of cloth symbolic of one's having taken on the "yoke of Christ"—upon a saint, presumably Simon Stock, the thirteenth-century English Carmelite friar who had a vision of this occurrence. Two donors kneel in the left middle distance with Saint Anthony of Padua. Among those also present are Saints Catherine of Siena; Dominic, accompanied by a dog holding a long taper in its mouth; Nicholas of Tolentino; Francis of Assisi, preaching to birds on the nearby bluff; and Raymond of Peñaforte, sailing across the sea on a billowing banner. The Feast of the Scapular was established in 1609, and the picture must date to about that time.

Though underappreciated today, Scarsellino was admired by his contemporaries. Giulio Mancini—that extraordinary physician and dilettante whose writings are so important for the study of seventeenth-century painting—considered him "among the best living masters in Italy." Scarsellino owed the color and refined naturalism of his paintings largely to Paolo Veronese, with whom he worked in Venice. This picture seems also to demonstrate his awareness of the innovations of the Carracci in Bologna.