A period of great change for the South Asian subcontinent. In the north, the declining Delhi Sultanate gives way to the Mughals, who establish the largest empire ever seen on the subcontinent. The arts flourish under Mughal patronage as a unique "Mughal style" emerges in painting and architecture, a synthesis of Indian and imported Persian influences. The south will see the rise and fall of the last great Hindu empire at Vijayanagar. The arrival of the Portuguese marks the beginning of European influence in the subcontinent, which will culminate in British rule in subsequent centuries.

• 1398 Delhi is sacked by Mongols led by Timur, but Tughluq sultans return to power upon their withdrawal. The Sayyid sultans rule from 1414, succeeded by the Lodis in 1451. Delhi-based sultanates never reestablish a strong political hold over the subcontinent.

• 15th century Jain manuscript painting traditions develop, as individual Jains commission texts for inclusion in temple libraries, primarily in western and northern regions. Stylistically quite distinct from Buddhist antecedents, the Jain style foreshadows later Rajput painting traditions in Rajasthan.

• 15th century Sri Lanka is politically divided into three main regions. In the north there is the Tamil kingdom at Jaffna, and Sinhala kingdoms centered in Kotte and Kandy. King Parakramabahu VI (r. 1412–67) manages to unite the island with a kingdom centered at the port city of Kotte for a brief period, but at the close of the century, the island is again divided between Kotte, Kandy, and Jaffna.

• 1459 Rao Jodha, the maharaja of Marwar, founds Jodhpur. He builds a large hill fort and sets the pattern for Rajput states.

• 1490 The governors of the four provinces of the Bahmanid sultanate in the Deccan break away, resulting in the formation of five smaller Deccani sultanates: Ahmadnagar, Berar, Bidar, Bijapur, and Golconda. The rulers of Bijapur, in particular, are great patrons of the arts.

• 1498 The Portuguese arrive on the western coast of India and establish trading posts.

• 1505 The Portuguese set up a trading post on Sri Lanka at Colombo. Roman Catholic missionaries become active in the coastal areas of the island. Portuguese control gradually spreads over the coastal areas, but the Tamil kingdom at Jaffna and the kingdom of Kandy in the central part of the island remain independent. Kandy becomes a Buddhist center as many monks flee persecution from areas under Portuguese influence.

• 1510 With their conquest of Goa, the Portuguese begin a century of control over the East Indies spice trade.

• 1526 Ibrahim Lodi (of the Afghan Lodi sultanate based in Delhi) is defeated by Babur (Timur's successor) in the Battle of Panipat, inaugurating the rule of the Mughal dynasty. From 1540 to 1555, Mughal control is lost to Afghan forces under Shir Shah Sur. After retreating to Persia, Humayan and his son Akbar reconquer the northern plains of South Asia and reestablish Mughal political dominance. At its height, the Mughal empire controls all of the northern subcontinent, from Bengal to Kabul to the Deccan.

While exiled in Persia during Shir Shah's interregnum, Humayun acquires the services of Safavid painters Mir Sayyid ^cAli and ^cAbd al-Samad.

• 1530s Nakaya governors break away from the Vijayanagar kingdom and form the Nakaya dynasties. The Nakayas become great patrons of Hindu temple construction.

• 1556 Akbar succeeds to the throne after the death of Humayan. He establishes an effective and comprehensive administrative system for the Mughal empire, and adopts a policy of tolerance toward local religious beliefs. His atelier of artists is influenced by local as well as imported traditions, experimenting with Persian painting styles, in dialogue with Jain, Hindu, and Sultanate styles, to create a unique "Mughal style."

• 1565 The Vijayanagar kingdom is captured and sacked by the armies of the Bahmanid sultanates, after a slow decline from the height of its power in the fifteenth century.

• 1567 The Mewar capital at Chitor is destroyed, leading to the construction of a second capital in the city of Udaipur (in present-day Rajasthan) under Rana Udai Singh (r. 1537–72). Rajput rulers are great patrons of the arts, including painting, which develops from indigenous precursors. Mughal painting styles are often influential, but many Rajput courts, like Mewar, retain indigenous styles.

• ca. 1574 Tulsidas begins the Ramcaritmanas, a Hindi vernacular version of the epic tale of the god-king Ram, whose wife Sita is kidnapped by the demon Ravana. The famous Sanskrit version of the epic was written in the closing centuries before the Common Era.

• 1577 Amritsar (in present-day Indian Punjab) is founded by Ram Das (1534–1581), fourth guru of the Sikhs.

• 1582 The Mughal emperor Akbar (r. 1556–1605) defines his syncretistic religious doctrine, Din-i Ilahi, or Divine Faith, and throughout his reign sponsors the extensive translation of Hindu texts, such as the Harivamsa (literally "Genealogy of Vishnu"). This sets the tone for the flowering of a syncretistic Mughal style in architecture and the arts, which occurs initially at the capital city of Fatehpur Sikri, near Agra, founded in 1571 but abandoned as a capital in 1585.

• 16th century The last Surya ruler (died 1540) of present-day Orissa becomes a disciple of Caitanya (1485–1533), the Bengali mystic and devotee of Krishna. Caitanya is associated with the Caitanya or Gaudiya sampraday (lineage), a highly influential Vaishnava sect. Later in the century, the Afghan rulers of Bengal incorporate Orissa; the Mughal empire takes control of Bengal in 1576 and Orissa in 1590–92.

• late 16th century Schools of miniature painting develop in the Deccan, first in Ahmadnagar, then in Bijapur and Golconda.

• 15th–17th centuries Devotional (bhakti) traditions emerge across the north, acting as a major impetus in the production of religious painting, manuscripts, and sculpture. Major poet-saints include Surdas, dedicated to Krishna, an avatar (incarnation) of Vishnu; Guru Nanak, the founder of the Sikh community; Kabir and Ravidas, lower caste saints; and Mirabai, the female devotee of Krishna from Rajasthan. Devotional poets advocate a personal and ecstatic interaction with god, often challenging Brahmanic and caste ideologies in their sometimes radical and egalitarian vision of the ultimate. Two primary visions of God predominate: saguna (according to which God can be experienced through the senses and in the immanent world) and nirguna (according to which God is unknowable through conventional sensory means).